Seppo W Langer Selected Research

Dexrazoxane (Zinecard)

1/2014	Dexrazoxane for the treatment of chemotherapy-related side effects.
2/2012	Treatment of experimental extravasation of amrubicin, liposomal doxorubicin, and mitoxantrone with dexrazoxane.
2/2010	A murine experimental anthracycline extravasation model: pathology and study of the involvement of topoisomerase II alpha and iron in the mechanism of tissue damage.
8/2007	Dexrazoxane for anthracycline extravasation.
1/2007	Other uses of dexrazoxane: Savene, the first proven antidote against anthracycline extravasation injuries.
1/2006	Treatment of anthracycline extravasation in mice with dexrazoxane with or without DMSO and hydrocortisone.
1/2004	Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent.
8/2003	Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide.

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Seppo W Langer Research Topics

Disease

33	Neoplasms (Cancer) 12/2022 - 08/2003
11	Lung Neoplasms (Lung Cancer) 10/2021 - 05/2008
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2022 - 06/2014
6	Wounds and Injuries (Trauma) 01/2014 - 01/2006
5	Neuroendocrine Carcinoma 01/2017 - 01/2012
5	Necrosis 11/2010 - 01/2003
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 05/2008
3	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/2020 - 06/2015
3	Brain Neoplasms (Brain Tumor) 10/2012 - 08/2003
2	Neoplasm Metastasis (Metastasis) 01/2021 - 05/2016
2	Adenocarcinoma 01/2020 - 01/2016
2	Cardiotoxicity 01/2014 - 01/2007
1	Carcinoid Tumor (Carcinoid) 01/2021
1	Edema (Dropsy) 01/2021
1	Lymphatic Metastasis 01/2021
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020
1	Insulinoma 12/2019
1	Ganglioneuroblastoma 12/2017
1	Liver Diseases (Liver Disease) 05/2016
1	Atherosclerosis 12/2015
1	Atherosclerotic Plaque (Atheroma) 12/2015
1	Neutropenia 10/2012
1	Pulmonary Embolism 10/2012
1	Thrombocytopenia (Thrombopenia) 10/2012
1	Fibrosis (Cirrhosis) 02/2010
1	Pathologic Complete Response 05/2008
1	Hand-Foot Syndrome 08/2003
1	Breast Neoplasms (Breast Cancer) 01/2003

Drug/Important Bio-Agent (IBA)

8	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2022 - 12/2015
8	64Cu-DOTATATEIBA 01/2022 - 06/2015
8	Dexrazoxane (Zinecard)FDA LinkGeneric 01/2014 - 08/2003
7	AnthracyclinesIBA 01/2014 - 01/2003
6	Etoposide (VP 16)FDA LinkGeneric 01/2020 - 08/2003
4	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 10/2021 - 12/2016
3	LigandsIBA 12/2022 - 01/2020
3	Immune Checkpoint InhibitorsIBA 04/2022 - 04/2017
3	alovudineIBA 10/2021 - 12/2016
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2021 - 05/2008
3	Chromogranin AIBA 10/2020 - 01/2017
2	Antineoplastic Agents (Antineoplastics)IBA 09/2021 - 08/2003
2	Glucagon (Glukagon)FDA Link 01/2021 - 12/2019
2	PlatinumIBA 01/2020 - 01/2017
2	Ga(III)-DOTATOCIBA 03/2017 - 12/2015
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2016
2	AntidotesIBA 08/2007 - 01/2007
1	Factor VII (Proconvertin)IBA 12/2022
1	Thromboplastin (Tissue Factor)IBA 12/2022
1	Urokinase Plasminogen Activator ReceptorsIBA 01/2022
1	Serotonin (5 Hydroxytryptamine)IBA 01/2021
1	Immune Checkpoint ProteinsIBA 01/2020
1	Cell-Free Nucleic AcidsIBA 01/2020
1	Insulin (Novolin)FDA Link 12/2019
1	ProinsulinIBA 12/2019
1	pentaerythrityl triacrylate (PETA)IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	SynaptophysinIBA 01/2017
1	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 07/2015
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/2015
1	Oxygen (Dioxygen)IBA 06/2014
1	Protein Kinase CIBA 10/2012
1	enzastaurinIBA 10/2012
1	AnthraquinonesIBA 02/2012
1	Carboplatin (JM8)FDA LinkGeneric 01/2012
1	Temozolomide (Temodar)FDA LinkGeneric 01/2012
1	Vincristine (Oncovin)FDA LinkGeneric 01/2012
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2010
1	MelatoninIBA 11/2010
1	IronIBA 02/2010
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 02/2010
1	Cisplatin (Platino)FDA LinkGeneric 05/2008
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2006
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2006
1	ICRF 198IBA 08/2003
1	MetalsIBA 08/2003
1	Epirubicin (Ellence)FDA LinkGeneric 01/2003

Therapy/Procedure

13	Therapeutics 01/2022 - 01/2007
13	Drug Therapy (Chemotherapy) 01/2021 - 01/2003
7	Radiotherapy 01/2022 - 10/2012
1	Drug Tapering 01/2022
1	Minimally Invasive Surgical Procedures 01/2021
1	Appendectomy 01/2021
1	Precision Medicine 12/2017
1	Combined Modality Therapy 12/2017
1	Radiofrequency Ablation 05/2016
1	Resistance Training 10/2013
1	Cranial Irradiation 05/2008